Mixtures of natural antimicrobials can reduce Campylobacter jejuni, Salmonella enterica and Clostridium perfringens infections and cellular inflammatory response in MDCK cells.
Igori BaltaAdela MarcuMark LintonCarmel KellyOzan GundogduLavinia StefIoan PetPatrick WardMyriam DeshaiesTodd CallawayPhittawat SopharatGratiela Gradisteanu-PircalabioruNicolae CorcionivoschiPublished in: Gut pathogens (2021)
The present study describes for the first time that mixtures of natural antimicrobials can prevent the formation of substrates used by bacterial pathogens to grow and survive in anaerobic environments (e.g. tetrathionate). Moreover, we provide further insights into pathogen invasion mechanisms through restoration of cellular structures and describe their ability to block the ERK-MAPK kinase pathway responsible for inflammatory cytokine release.
Keyphrases
- inflammatory response
- signaling pathway
- induced apoptosis
- pi k akt
- ionic liquid
- oxidative stress
- cell cycle arrest
- microbial community
- antimicrobial resistance
- wastewater treatment
- lipopolysaccharide induced
- escherichia coli
- cell migration
- gram negative
- endoplasmic reticulum stress
- protein kinase
- staphylococcus aureus
- sewage sludge
- immune response
- risk assessment
- tyrosine kinase
- mass spectrometry
- cell death