Direct, indirect and total effect of HIV coinfection on the risk of non-liver-related cancer in hepatitis C virus-infected patients treated by direct-acting antivirals: a mediation analysis.
Mathieu ChalouniStanislas PolPhilippe SogniHelene FontaineKarine LacombeJean-Marc LacombeLaure EsterleCéline DorivalMarc BourlièreFirouzé Bani-SadrVictor de LedinghenDavid ZucmanDominique LarreyDominique SalmonFabrice CarratLinda Wittkopnull nullV MartinezPublished in: HIV medicine (2021)
In HCV participants treated with DAAs, the direct effect of HIV coinfection, reflecting chronic inflammation and immunosuppression, was associated with a 3.7-fold higher risk of non-liver-related cancer. By contrast, the indirect effect of HIV coinfection, reflecting higher tobacco and alcohol consumption and metabolic dysregulation, was not significantly associated with the risk of non-liver-related cancers.
Keyphrases
- hepatitis c virus
- human immunodeficiency virus
- antiretroviral therapy
- hiv positive
- hiv infected
- hiv testing
- alcohol consumption
- papillary thyroid
- hiv aids
- men who have sex with men
- squamous cell
- magnetic resonance
- computed tomography
- magnetic resonance imaging
- young adults
- lymph node metastasis
- drug induced
- depressive symptoms
- childhood cancer