Genomic analysis of recurrences and high-grade forms of polymorphous adenocarcinoma.
Ana P M SebastiaoFresia ParejaRahul KumarDavid N BrownCatarina SilveiraEdaise M da SilvaJu Y LeeAngela DelNora KatabiSimion ChioseaBritta WeigeltJorge Sergio Reis-FilhoRaja R SeethalaPublished in: Histopathology (2019)
Our findings demonstrate that recurrent and high-grade PACs are underpinned by PRKD1 E710D hotspot mutations or PRKD2 rearrangements, and that recurrences of PACs may stem from the selection of pre-existing subclones in the primary tumour.