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Medical history of chemotherapy or immunosuppressive drug treatment and risk of amyotrophic lateral sclerosis (ALS).

Thomas KuczmarskiElijah W StommelKristen RileyRup TandanVinay ChaudhryLora ClawsonTracie A CallerPatricia L HeneganDominic N FacciponteWalter G BradleyAngeline S Andrew
Published in: Journal of neurology (2017)
A recent population-based analysis demonstrated lower risk of the lethal degenerative neuromuscular disease, amyotrophic lateral sclerosis (ALS) associated with history of the use of 'antineoplastic agents' and 'immunosuppressants'. To see if this finding was generalizable to other ALS cohorts, we examined associations between use of these agents and ALS risk in an independent case-control study of n = 414 ALS patients and n = 361 controls in an Eastern US population. Controls were sampled from the general population and among non-neurodegenerative disease patients. A history of chemotherapy treatment was significantly associated with a decreased ALS risk (OR 0.46, 95% CI 0.22-0.89, P = 0.026). We did not observe an association between risk of ALS and immunosuppressant therapy use (OR 0.78, 95% CI 0.50-1.02, P = 0.23). Analyses were adjusted for age, gender, and smoking. Our results support the prior report for chemotherapy treatment and lead to further discussion of the underlying mechanism.
Keyphrases
  • amyotrophic lateral sclerosis
  • end stage renal disease
  • newly diagnosed
  • healthcare
  • emergency department
  • locally advanced
  • south africa
  • replacement therapy
  • bone marrow
  • electronic health record
  • drug induced