Effect of postdose fasting duration on hetrombopag olamine pharmacokinetics and pharmacodynamics in healthy volunteers.
Guoping YangRanglang HuangShuang YangXingfei ZhangXiaoyan YangHonghui ChenZhijun HuangChengxian GuoQi PeiYanfei TaiYancong ShenJie HuangChan ZouPublished in: British journal of clinical pharmacology (2020)
Hetrombopag was well tolerated in healthy male subjects under fasted/fed conditions. The shorter fasting duration resulted in lower hetrombopag exposure, corresponding to a lower level of platelet elevation. Therefore, we recommended oral administration of hetrombopag on an empty stomach (fasting condition) or at least 2 hours before a meal to achieve maximum bioavailability.