Portosystemic shunting prevents hepatocellular carcinoma in non-alcoholic fatty liver disease mouse models.

Andrea PelosoStéphanie LacotteQuentin GexFlorence SlitsBeat MoeckliGraziano OldaniMatthieu TihyAurélie HautefortBrenda KwakLaura Rubbia-BrandtChristian Toso

Published in: PloS one (2023)

The present data show that portosystemic shunting prevents NAFLD-associated HCC, utilizing two independent mouse models. This effect is supported by the development of less steatosis, and a restored liver oxygen level. Portal pressure modulation and shunting deserve further exploration as potential prevention/treatment options for NAFLD and HCC.

Keyphrases

mouse model
insulin resistance
electronic health record
high fat diet
big data
type diabetes
metabolic syndrome
liver fibrosis
machine learning
skeletal muscle
data analysis