Evaluation of the interaction between polymyxin B and Pseudomonas aeruginosa biofilm and planktonic cells: reactive oxygen species induction and zeta potential.
Marlucy Rodrigues LimaGabriella Freitas FerreiraWallace Ribeiro Nunes NetoJoveliane de Melo MonteiroÁquila Rodrigues Costa SantosPriscila Batista TavaresÂngelo Márcio Leite DenadaiMaria Rosa Quaresma BomfimVera Lúcia Dos SantosSirlei Garcia MarquesAndrea de Souza MonteiroPublished in: BMC microbiology (2019)
Oxidative burst generated by planktonic and sessile cells from P. aeruginosa strains against polymyxin B indicates that ROS may have an important role in the mechanism of action of this drug. ZP data revealed that electrostatic interactions of the cationic peptide with the anionic surface of the cells are strain-dependent. Therefore, we suggested that the intracellular effects of polymyxin B should be further investigated to understand polymyxin B-induced stress in P. aeruginosa.
Keyphrases
- reactive oxygen species
- pseudomonas aeruginosa
- induced apoptosis
- cell cycle arrest
- gram negative
- cell death
- cystic fibrosis
- staphylococcus aureus
- escherichia coli
- signaling pathway
- oxidative stress
- electronic health record
- multidrug resistant
- drug induced
- diabetic rats
- acinetobacter baumannii
- machine learning
- molecular dynamics simulations
- big data
- risk assessment
- drug resistant
- pi k akt