ANCA-associated kidney disease preceded by orbital pseudotumor.

Ileisa OlesonAdeline FeckerKelsey RichardsonAbbie BauerNicole K AndeenVanderlene L Kung

Published in: Pediatric nephrology (Berlin, Germany) (2023)

In isolation, TBM deposits and increased IgG4 + plasma cells are suggestive of IgG4-RD. In the context of a positive ANCA and pauci-immune crescentic glomerulonephritis, however, increased IgG4 + plasma cells due to AAV are favored. In cases with features of IgG4-RD, ANCA positivity suggests an alternate diagnosis of AAV to be more likely.

Keyphrases

induced apoptosis
cell cycle arrest
cell death
oxidative stress
signaling pathway
gene therapy
pi k akt