The spectrum of mitochondrial DNA (mtDNA) mutations in pediatric CNS tumors.

Kristiyana KanevaKatrina O'HalloranPetr TriskaXiyu LiuDaria MerkurjevMoiz BootwallaAlex RyutovJennifer A CotterDejerianne OstrowJaclyn A BiegelXiaowu Gai

Published in: Neuro-oncology advances (2021)

Our findings demonstrate varying contributions of mtDNA mutations in different subtypes of CNS tumors. Sequencing the mtDNA genome may ultimately be used to characterize CNS tumors at diagnosis and monitor disease progression.

Keyphrases

mitochondrial dna
copy number
blood brain barrier
genome wide
dna methylation
gene expression
single cell
young adults