Akt/mTOR-Mediated Autophagy Confers Resistance To BET Inhibitor JQ1 In Ovarian Cancer.

Wenqing LuanYingxin PangRui LiXuan WeiXiaoxiao JiaoJuanjuan Shi Jiangtao YuHongluan MaoPei-Shu Liu

Published in: OncoTargets and therapy (2019)

These findings revealed that JQ1-induced pro-survival autophagy might be a potential mechanism in the resistance of ovarian cancer cells to BET inhibition by JQ1. Combination of JQ1 and autophagy inhibitors could be an effective therapeutic strategy for overcoming BET inhibitor resistance in ovarian cancer.

Keyphrases

signaling pathway
cell death
endoplasmic reticulum stress
oxidative stress
cell proliferation
risk assessment
free survival