HIF-1α limits myocardial infarction by promoting mitophagy in mouse hearts adapted to chronic hypoxia.

Petra AlanovaLukas AlanBarbora OpletalovaRomana BohuslavovaPavel AbaffyKaterina MatejkovaKristyna HolzerovaDaniel BenakNina KaludercicRoberta MenaboFabio Di LisaBohuslav OstadalFrantisek KolarGabriela Pavlinkova

Published in: Acta physiologica (Oxford, England) (2024)

These findings provide new insights into the contribution of HIF-1α to cardiomyocyte survival during acute ischemia/reperfusion injury by activating the selective autophagy pathway.

Keyphrases

ischemia reperfusion injury
endothelial cells
signaling pathway
oxidative stress
liver failure
drug induced
cell death
high glucose
respiratory failure
heart failure
endoplasmic reticulum stress
left ventricular
angiotensin ii
aortic dissection
free survival
nlrp inflammasome
hepatitis b virus