Clonal hematopoiesis of indeterminate potential in patients with acute coronary syndrome undergoing percutaneous coronary intervention in the absence of traditional risk factors.
Zaixin JiangYi LiChenghui YanXiaolin ZhangQuanyu ZhangJing LiXiaoxiang TianMiaohan QiuZhenyang LiangSichong MaKun NaZiqi LiSanbao ChenYu ZhaoZizhao QiXiying LiuYa-Ling HanPublished in: Clinical research in cardiology : official journal of the German Cardiac Society (2022)
The most frequent CHIP-related mutations, DNMT3A, TET2, and ASXL1 are significantly associated with increased risk of recurrent cardiovascular events. Our study may be valuable target to reduce residual risk in patients with ACS carrying specific mutations.
Keyphrases
- cardiovascular events
- coronary artery disease
- percutaneous coronary intervention
- acute coronary syndrome
- risk factors
- cardiovascular disease
- acute myocardial infarction
- st segment elevation myocardial infarction
- dna methylation
- st elevation myocardial infarction
- antiplatelet therapy
- coronary artery bypass grafting
- high throughput
- atrial fibrillation
- circulating tumor cells
- heart failure
- risk assessment
- type diabetes
- human health
- fine needle aspiration