A clinical, histopathological and laboratory study of 19 consecutive Italian paediatric patients with chilblain-like lesions: lights and shadows on the relationship with COVID-19 infection.

M El HachemAndrea DiociaiutiC ConcatoR CarsettiC CarnevaleM Ciofi Degli AttiL GiovannelliE LatellaO PorzioS RossiA StracuzziS ZaffinaA Onetti MudaG ZambrunoR Alaggio

Published in: Journal of the European Academy of Dermatology and Venereology : JEADV (2020)

Chilblain-like lesions during COVID-19 pandemic have specific epidemiologic, clinical, capillaroscopic and histopathological characteristics, which distinguish them from idiopathic perniosis. Though we could not formally prove SARS-CoV-2 infection in our patients, history data and the detection of anti-SARS-COV-2 IgA strongly suggest a relationship between skin lesions and COVID-19. Further investigations on the mechanisms of SARS-CoV-2 infection in children and pathogenesis of chilblain-like lesions are warranted.

Keyphrases

sars cov
respiratory syndrome coronavirus
end stage renal disease
coronavirus disease
ejection fraction
newly diagnosed
chronic kidney disease
emergency department
intensive care unit
prognostic factors
patient reported outcomes
electronic health record
quantum dots
artificial intelligence