Anticancer potential of biologically synthesized silver nanoparticles using Lantana camara leaf extract.
Leena V HublikarSharanabasava V GanachariVeerabhadragouda B PatilSahana NandiAishwarya HonnadPublished in: Progress in biomaterials (2023)
A Lantana camara leaf (LC) extract was used as a mild reducing agent to produce silver metal nanoparticles (LC-AgNPs) efficiently. The size, shape, and morphology of synthesized silver nanoparticles were verified. LC-AgNPs were found in LC extract by XRD. The optimal concentrations of silver nitrate and LC extract necessary for the production of stable silver nanoparticles were determined. The LC-AgNPs were found spherical in form and monodispersed. Under optimal conditions, the round LC-AgNPs of 50-90 nm were utilized to cure lung cancer (A549 cell line) and breast cancer (MCF7) cell lines. Finally, the produced LC-AgNPs enhanced anti-cancer efficacy against A549 cells, with an IC50 = 49.52 g/mL. Similarly, the effect of LC-AgNPs on MCF7 cell line was assessed using an MTT test and inhibitory concentration (IC50) was determined found that 46.67 g/mL.
Keyphrases
- silver nanoparticles
- simultaneous determination
- mass spectrometry
- liquid chromatography
- tandem mass spectrometry
- nitric oxide
- solid phase extraction
- signaling pathway
- breast cancer cells
- cell death
- gold nanoparticles
- drinking water
- climate change
- pi k akt
- endoplasmic reticulum stress
- anti inflammatory
- cell proliferation
- gas chromatography