Hydrophobic interactions between the HA helix and S4-S5 linker modulate apparent Ca2+ sensitivity of SK2 channels.

Young-Woo NamMeng CuiRazan OrfaliAdam ViegasMisa NguyenEman H M MohammedKhalid A ZoghebiSimin RahighiKeykavous ParangMiao Zhang

Published in: Acta physiologica (Oxford, England) (2020)

The electrophysiological data and MD simulations collectively suggest a crucial role of the interactions between the HA helix and S4-S5 linker in the apparent Ca2+ sensitivity of SK2 channels.

Keyphrases

molecular dynamics
diffusion weighted imaging
dna binding
electronic health record
protein kinase
ionic liquid
monte carlo
deep learning
aqueous solution