Acute pyelonephritis: Increased plasma membrane targeting of renal aquaporin-2.
Christina V ErnstsenFrédéric H LoginAnne-Sofie B ScheldeJacob R TherkildsenJakob Møller-JensenRikke NørregaardHelle PraetoriusLene N NejsumPublished in: Acta physiologica (Oxford, England) (2022)
Uropathogenic bacteria induce AQP2 plasma membrane targeting in vitro and in vivo. cAMP levels were not elevated by the bacterial lysates and AQP2 plasma membrane targeting could occur without S256 phosphorylation. This may explain increased AQP2 excretion in the urine during acute pyelonephritis.