Analysis of oligonucleotides by ion-pairing hydrophilic interaction liquid chromatography/electrospray ionization mass spectrometry.

Published in: Rapid communications in mass spectrometry : RCM (2018)

The HILIC-LC/MS method with the addition of TEAA at a MS-compatible concentration has improved the separation of oligonucleotides. The IP-HILIC-LC/MS method also produces very simple mass spectra with high desalting efficiency.

Keyphrases

liquid chromatography
mass spectrometry
high resolution mass spectrometry
tandem mass spectrometry
gas chromatography
simultaneous determination
high performance liquid chromatography
capillary electrophoresis
solid phase extraction
high resolution
nucleic acid
multiple sclerosis
ms ms