Pyridoxine Preferentially Induces Auditory Neuropathy Through Mitochondrial Dysfunction and Endoplasmic Reticulum Stress-Mediated Apoptosis.

Channy ParkHyewon LimSung K Moon Raekil Park

Published in: The Annals of otology, rhinology, and laryngology (2019)

Pyridoxine preferentially induced severe cell death on nerve fiber in primary OC explants and markedly increased apoptotic cell death via mitochondria-mediated ER stress in VOT-33 cells.

Keyphrases

cell death
endoplasmic reticulum stress
induced apoptosis
cell cycle arrest
oxidative stress
signaling pathway
diabetic rats
drug induced
high glucose
working memory
early onset
cell proliferation