Rational selection of antifungal drugs to propose a new formulation strategy to control Candida biofilm formation on venous catheters.
Paula ReginattoVanessa Zafanelli BergamoSimone Jacobus BerlitzIrene Clemes Kulkamp GuerreiroSaulo Fernandes de AndradeAlexandre Meneghello FuentefriaPublished in: Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] (2020)
Due to the superiority of anidulafungin and the synergistic activity of the combination, these alternatives were the most promising options for use in a formulation proposal as a new strategy to combat the Candida spp. biofilm. These formulations demonstrated high in vitro performance in the prevention of biofilms, indicating that they are candidates with great potential for in vivo tests.