Inflammasome Activation Induced by a Snake Venom Lys49-Phospholipase A2 Homologue.

Charles Nunes BoenoMauro Valentino PaloschiJéssica Amaral LopesWeverson Luciano PiresSulamita da Silva SetúbalJaína Rodrigues EvangelistaAndreimar Martins SoaresJuliana Pavan Zuliani

Published in: Toxins (2019)

Together, the results showed for the first time that BthTX-I in gastrocnemius muscle induces inflammation and consequently, inflammasome activation via NLRP3 with caspase-1 activation and IL-1β liberation.

Keyphrases

cell death
induced apoptosis
endoplasmic reticulum stress
nlrp inflammasome