Immunization with an adenovirus-vectored TB vaccine containing Ag85A-Mtb32 effectively alleviates allergic asthma.

Yiling ZhangYing FengLiang LiXianmiao YeJinlin WangQian WangPingchao LiNa LiXuehua ZhengXiang GaoChufang LiFeng LiBaoqing SunKefang LaiZhong SuNanshan ZhongLing ChenLiqiang Feng

Published in: Journal of molecular medicine (Berlin, Germany) (2018)

•Ad5-gsgAM elicits Th1 responses and suppresses Th2-mediated allergic asthma in mice. •Ad5-gsgAM inhibits IL-33/ST2 axis by reducing IL-33 secretion but not ILC2 recruiting. •Treg is essential for modulating Th2 responses and IL-33/ST2 axis by Ad5-gsgAM.

Keyphrases

allergic rhinitis
chronic obstructive pulmonary disease
mycobacterium tuberculosis
lung function
signaling pathway
pulmonary tuberculosis
cystic fibrosis
metabolic syndrome
gene therapy
wild type