Dimethyl fumarate modulates neutrophil extracellular trap formation in a glutathione- and superoxide-dependent manner.

Jochen H O HoffmannK SchaekelD HartlA H EnkE N Hadaschik

Published in: The British journal of dermatology (2017)

We report DMF as a potent, stimulus-specific, GSH- and ROS-dependent modulator of NET formation. Our results support the notion that modulation of NET formation contributes to the beneficial effects of FAEs in a variety of inflammatory conditions.

Keyphrases

oxidative stress
cell death
dna damage
hydrogen peroxide
reactive oxygen species
nitric oxide