The Effect of Intraocular Pressure Load Boundary on the Biomechanics of the Human Conventional Aqueous Outflow Pathway.

Alireza Karimi Reza Razaghi Seyed Mohammadali RahmatiJ Crawford DownsTed S AcottMary J KelleyRuikang K WangMurray Johnstone

Published in: Bioengineering (Basel, Switzerland) (2022)

Transient IOP fluctuations may cause a relatively large IOP difference of ~20 mmHg in a very short time frame of ~0.1 s, resulting in a rate stiffening in the outflow tissues. Rate stiffening reduces strains and causes a rate-dependent pressure gradient across the outflow tissues. Thus, the results suggest it is necessary to use a viscoelastic material model in outflow tissues that includes the important role of IOP load rate.

Keyphrases

gene expression
endothelial cells
mass spectrometry
high resolution
induced pluripotent stem cells