Germline Sequencing DNA Repair Genes in 5545 Men With Aggressive and Nonaggressive Prostate Cancer.
Burcu F DarstTokhir DadaevEd SaundersXin ShengPeggy WanLoreall PoolerLucy Y XiaStephen J ChanockSonja I BerndtSusan M GapsturVictoria L StevensDemetrios AlbanesStephanie J WeinsteinVincent GnanapragasamGraham G GilesTu Nguyen-DumontRoger L MilneMark M PomerantzJulie A SchmidtLorelei MucciWilliam J CatalonaKurt N HetrickKimberly F DohenyRobert J MacInnisMelissa C SoutheyRosalind A EelesFredrik WiklundZsofia Kote-JaraiDavid V ContiChristopher A HaimanPublished in: Journal of the National Cancer Institute (2022)
Risk conveyed by DNA repair genes is largely driven by rare P/LP/D alleles within BRCA2, PALB2, and ATM. These findings support the importance of these genes in both screening and disease management considerations.