Endothelial Natriuretic Peptide Receptor 1 Play Crucial Role for Acute and Chronic Blood Pressure Regulation by Atrial Natriuretic Peptide.
Takeshi TokudomeKentaro OtaniYuanjie MaoLars Jørn JensenYuji AraiTakahiro MiyazakiTakashi SonobeJames T PearsonTsukasa OsakiNaoto MinaminoJunji IshidaAkiyoshi FukamizuHayato KawakamiDaisuke OnozukaKunihiro NishimuraMikiya MiyazatoHirohito NishimuraPublished in: Hypertension (Dallas, Tex. : 1979) (2022)
Together, these results indicate that vascular endothelial NPR1 plays a crucial role in ANP-mediated blood pressure regulation, presumably by a mechanism that is RGS2-dependent in the acute phase and RGS2-independent in the chronic phase.