A MAA-based dosimetric study in patients with intrahepatic cholangiocarcinoma treated with a combination of chemotherapy and 90Y-loaded glass microsphere selective internal radiation therapy.
Vincent ManceauXavier PalardYan RollandMarch PrachtSamuel Le SourdSophie LaffontKarim BoudjemaAstride LievreHabiba MesbahLaure-Anne HaumontLaurence LenoirVanessa BrunThomas UguenJulien EdelineEtienne GarinPublished in: European journal of nuclear medicine and molecular imaging (2018)
When combined with chemotherapy, SIRT is highly effective, with a TD > 158Gy. Tolerance was good except for the few patients with cirrhosis or Child-Pugh status ≥A6, who exhibited some liver toxicity. Prospective studies are warranted to confirm.