Direct Reprogramming Improves Cardiac Function and Reverses Fibrosis in Chronic Myocardial Infarction.
Hidenori TaniTaketaro SadahiroYu YamadaMari IsomiHiroyuki YamakawaRyo FujitaYuto AbeTatsuya AkiyamaKoji NakanoYuta KuzeMasahide SekiYutaka SuzukiManabu FujisawaMamiko Sakata-YanagimotoShigeru ChibaKeiichi FukudaMasaki IedaPublished in: Circulation (2022)
These results demonstrate that cardiac reprogramming could repair chronic MI by means of myocardial regeneration and reduction of fibrosis. These findings present opportunities for the development of new therapies for chronic MI and heart failure.