Clinical and genetic characteristics of 1672 cases of amyotrophic lateral sclerosis in China: a single-center retrospective study.

Dongchao ShenXunzhe YangDi HeKang ZhangShuangwu LiuXiaohan SunJinyue LiZhengyi CaiMingsheng LiuXue ZhangQing LiuLiying Cui

Published in: Journal of neurology (2024)

This study provides comprehensive data on the genetic characteristics of ALS patients in China through large-scale clinical data and genetic analysis of 1672 cases. Differences in age of onset, onset site, and clinical phenotype among ALS patients with different genotypes can help clinicians better predict disease progression and provide a basis for precise diagnosis and individualized treatment.

Keyphrases

amyotrophic lateral sclerosis
end stage renal disease
newly diagnosed
chronic kidney disease
palliative care
machine learning
prognostic factors
peritoneal dialysis
gene expression
data analysis
deep learning