Asymmetric synthesis of CF2-functionalized aziridines by combined strong Brønsted acid catalysis.

Published in: Beilstein journal of organic chemistry (2020)

A diastereo- and enantioselective approach to access chiral CF2-functionalized aziridines from difluorodiazoethyl phenyl sulfone (PhSO2CF2CHN2) and in situ-formed aldimines is described. This multicomponent reaction is enabled by a combined strong Brønsted acid catalytic platform consisting of a chiral disulfonimide and 2-carboxyphenylboronic acid. The optical purity of the obtained CF2-substituted aziridines could be further improved by a practical dissolution-filtration procedure.

Keyphrases

cystic fibrosis
quantum dots
ionic liquid
molecular docking
capillary electrophoresis
high throughput