Infigratinib in upper tract urothelial carcinoma versus urothelial carcinoma of the bladder and its association with comprehensive genomic profiling and/or cell-free DNA results.

Sumanta Kumar PalDean BajorinNazli DizmanJean Hoffman-CensitsDavid I QuinnDaniel P PetrylakMatthew D GalskyUlka N VaishampayanUgo De GiorgiSumati GuptaHoward A BurrisHarris S SoiferGary LiHao WangCarl L DambkowskiSusan MoranSiamak DaneshmandJonathan E Rosenberg

Published in: Cancer (2020)

Differences in the cumulative genomic profile were observed between patients with UTUC and those with UCB in the current FGFR3-restricted experience, underscoring the distinct biology of these diseases. These results support a planned phase 3 adjuvant study predominantly performed in this population.

Keyphrases

copy number
single cell
gene expression
genome wide