Genetic underpinnings of fasting and oral glucose-stimulated based insulin sensitivity indices.

Sufyan Suleman Anne Lundager Madsen Lars H Ängquist Mikkel Schubert Allan Linneberg Ruth J F Loos Torben Hansen Niels Grarup

Published in: The Journal of clinical endocrinology and metabolism (2024)

Even though the IS indices mostly share a common genetic background, notable differences emerged between OGTT0,120 indices. The fasting and OGTT based indices have distinct associations with T2D risk variants. This work provides a basis for future large-scale genetic investigations into the differences between IS indices.

Keyphrases

copy number
blood glucose
genome wide
insulin resistance
gene expression
blood pressure
metabolic syndrome
current status
skeletal muscle
weight loss