In Vitro Model of Stretch-Induced Lung Injury to Study Different Lung Ventilation Regimens and the Role of Sedatives.

Yusuke MitsuiSophia KoutsogiannakiMiho FujiogiKoichi Yuki

Published in: Translational perioperative and pain medicine (2020)

We described the in vitro cyclic stretch system mimicking high and low TV ventilation. High TV mimetic was associated with increased cell death. Dexmedetomidine attenuated the degree of cell death.

Keyphrases

cell death
cell cycle arrest
respiratory failure
mechanical ventilation
high glucose
diabetic rats
cardiac surgery
intensive care unit
signaling pathway
cell proliferation
acute kidney injury