Circular RNA hsa_circ_0004872 inhibits gastric cancer progression via the miR-224/Smad4/ADAR1 successive regulatory circuit.

Cunying MaXiaoying WangFenghua YangYichen ZangJiansong LiuXinyi WangXia XuWenjuan LiJihui JiaZhifang Liu

Published in: Molecular cancer (2020)

Our findings showed that hsa_circ_0004872 acted as a tumor suppressor in GC by forming a negative regulatory loop consisting of hsa_circ_0004872/miR-224/Smad4/ADAR1. Thus, hsa_circ_0004872 may serve as a potential biomarker and therapeutic target for GC.

Keyphrases

cell proliferation
long non coding rna
transcription factor
epithelial mesenchymal transition
long noncoding rna
transforming growth factor
signaling pathway
liquid chromatography