Oral application of levosimendan before ischaemia/reperfusion with or without cardioplegic arrest in rats.
Andreas BoeningEdgar WelkMartina HeepCarina HemmerichBernd NiemannKlaus-Dieter SchlüterZulfugar T TaghiyevPublished in: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery (2022)
Levosimendan applied orally before ischaemia/reperfusion improves functional recovery, but this effect is only moderate when cardioplegia is included. Differences between hearts exposed to cardioplegia or to global ischaemia may indicate why levosimendan-related beneficial effects do not directly translate into better clinical outcome.