Investigating the interaction between nifedipine- and ritonavir-containing antiviral regimens: A physiologically based pharmacokinetic/pharmacodynamic analysis.

Wanjie NiuSize LiShasha JinXiying LinMengwan ZhangWei-Min Cai Zheng Jiao Xiao-Qiang Xiang

Published in: British journal of clinical pharmacology (2020)

Ritonavir significantly affects the pharmacokinetics and antihypertensive effect of nifedipine. It is not recommended for patients to take nifedipine- and ritonavir-containing regimens simultaneously.

Keyphrases

end stage renal disease
antiretroviral therapy
newly diagnosed

ejection fraction
chronic kidney disease
blood pressure

peritoneal dialysis
patient reported outcomes

patient reported
hypertensive patients