Cost-effectiveness of the McGill interactive pediatric oncogenetic guidelines in identifying Li-Fraumeni syndrome in female patients with osteosarcoma.

Juan David RiosFrances SimbulanLara ReichmanKimberly CaswellMelissa TachdjianDavid MalkinCecilia CottonPaul C Nathan Catherine Goudie Petros Pechlivanoglou

Published in: Pediatric blood & cancer (2024)

This study provides evidence for clinical and policy decision-making on the cost-effectiveness of genetic referral strategies to identify LFS in the setting of osteosarcoma. MIPOGG-guided strategy was most likely to be cost-effective at a willingness-to-pay threshold value of $50,000/QALY.

Keyphrases

decision making
public health
primary care
mental health
genome wide
health insurance
copy number
gene expression
young adults