MALDI-MS in first-line screening of newborns for sickle cell disease: results from a prospective study in comparison to HPLC.

Marven El OstaJean-François BenoistPierre NaubourgStéphane BonacorsiReine MessinePatrick DucoroyBichr Allaf

Published in: Clinical chemistry and laboratory medicine (2024)

is adapted to NBS for SCD, and can be used in first-line high-throughput screening to detect HbS, and beta-thalassemia major warning. When HbS is detected, second-line use of another specific method as HPLC is necessary.

Keyphrases

sickle cell disease
ms ms
mass spectrometry
high performance liquid chromatography
simultaneous determination
liquid chromatography
solid phase extraction
tandem mass spectrometry
pregnant women
low birth weight
high resolution
gestational age
cord blood
preterm infants
preterm birth