RNF130 Regulates LDLR Availability and Plasma LDL Cholesterol Levels.

Bethan L CliffordKelsey E JarrettJoan ChengAngela ChengMarcus SeldinPauline MorandRichard LeeMary ChenAngel BaldanThomas Q de Aguiar VallimElizabeth J Tarling

Published in: Circulation research (2023)

Our studies identify RNF130 as a novel posttranslational regulator of LDL-C levels via modulation of LDLR availability, thus providing important insight into the complex regulation of hepatic LDLR protein levels.

Keyphrases

low density lipoprotein
transcription factor
dna damage response
small molecule
amino acid