Mitochondrial morphology and MAVS-IFN1 signaling pathway in muscles of anti-MDA5 dermatomyositis.
Yanyan JiangYilin LiuYawen ZhaoYiming ZhengMeng YuJianwen DengHongjun HaoWei ZhangZhaoxia WangYun YuanPublished in: Annals of clinical and translational neurology (2021)
Compared to antibody-negative DM, we presented a different distribution of the mitochondrial pathology and less severe morphology in anti-MDA5 DM. We also revealed the enhanced but less intensive MAVS-IFN1 signaling pathway activity in muscles of anti-MDA5 DM. Such disparity suggested the potentially different mechanism of muscle injury in two DM groups.
Keyphrases
- signaling pathway
- breast cancer cells
- pi k akt
- oxidative stress
- glycemic control
- cell cycle arrest
- immune response
- dendritic cells
- epithelial mesenchymal transition
- induced apoptosis
- type diabetes
- early onset
- rheumatoid arthritis
- metabolic syndrome
- interstitial lung disease
- single cell
- adipose tissue
- disease activity
- systemic lupus erythematosus
- systemic sclerosis