Calycosin inhibited MIF-mediated inflammatory chemotaxis of macrophages to ameliorate ischemia reperfusion-induced acute kidney injury.

Hong-Lian WangZe PengYu-Qing LiYi-Xuan WangJian-Chun LiRui-Zhi TanHong-Wei SuHong-Ping ShenChang-Ying ZhaoJian LiuLi Wang

Published in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2024)

In summary, calycosin attenuates IRI-AKI by inhibiting MIF-mediated macrophage inflammatory chemotaxis, suggesting it could be a promising therapeutic agent for the treatment of IRI-AKI.

Keyphrases

acute kidney injury
oxidative stress
adipose tissue
signaling pathway
high glucose
endothelial cells
stress induced