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An emerging role for tissue plasticity in developmental precision.

Sundar Ram Naganathan
Published in: Biochemical Society transactions (2024)
Reproducible tissue morphology is a fundamental feature of embryonic development. To ensure such robustness during tissue morphogenesis, inherent noise in biological processes must be buffered. While redundant genes, parallel signaling pathways and intricate network topologies are known to reduce noise, over the last few years, mechanical properties of tissues have been shown to play a vital role. Here, taking the example of somite shape changes, I will discuss how tissues are highly plastic in their ability to change shapes leading to increased precision and reproducibility.
Keyphrases
  • gene expression
  • signaling pathway
  • air pollution
  • machine learning
  • deep learning
  • oxidative stress
  • dna methylation
  • epithelial mesenchymal transition
  • pi k akt