Lifelong exposure to high-altitude hypoxia in humans is associated with improved redox homeostasis and structural-functional adaptations of the neurovascular unit.

) and lower concentrations of S100B, neurofilament-light chain (NF-L) and total tau (T-Tau) in the face of preserved cerebral bioenergetics and cognition. Collectively, our novel findings tentatively suggest that these integrated adaptations may collectively reflect a neuroprotective phenotype to cope with the lifelong stress of high-altitude hypoxia. MCA, middle cerebral artery; PCA, posterior cerebral artery; ICA, internal carotid artery; VA, vertebral artery. This article is protected by copyright. All rights reserved.