Plasma peroxiredoxin changes and inflammatory cytokines support the involvement of neuro-inflammation and oxidative stress in Autism Spectrum Disorder.
P M AbruzzoA MattéA BolottaE FedertiA GhezzoT GuarnieriMarina MariniA PosarA SicilianoL De FranceschiP ViscontiPublished in: Journal of translational medicine (2019)
Previous findings reported elevated inflammatory cytokines in the plasma of ASD children, without clearly pointing to the presence of neuro-inflammation. On the other hand, the finding of microglia activation in autoptic specimens was clearly suggesting the presence of neuro-inflammation in ASD. Given the role of peroxiredoxins in the protection of brain cells against oxidative stress, the whole of our results, using peripheral data collected in living patients, support the involvement of neuro-inflammation in ASD, and generate a rational for neuro-inflammation as a possible therapeutic target and for plasma Prx5 as a novel indicator of ASD severity.
Keyphrases
- oxidative stress
- autism spectrum disorder
- induced apoptosis
- attention deficit hyperactivity disorder
- intellectual disability
- dna damage
- diabetic rats
- ischemia reperfusion injury
- end stage renal disease
- young adults
- newly diagnosed
- ejection fraction
- inflammatory response
- chronic kidney disease
- machine learning
- prognostic factors
- cell proliferation
- heat shock
- peritoneal dialysis
- working memory
- deep learning
- brain injury
- artificial intelligence
- patient reported