TAK1 safeguards endothelial cells from gut microbes and inflammation.

Published in: Molecular & cellular oncology (2019)

How endothelial cells (ECs) survive in inflammatory environments remains unclear. We recently showed that TAK1 protects ECs against apoptosis induced by TNFα under physiological conditions in the intestine and liver, and under inflammatory conditions in other organs. Our results document that a single gene can affect cell fate decisions in mature ECs.

Keyphrases

oxidative stress
endothelial cells
cell fate
rheumatoid arthritis
endoplasmic reticulum stress
high glucose
copy number
vascular endothelial growth factor
dna methylation
transcription factor
genome wide analysis