In Vivo Assessment of Neuroinflammation in 4-Repeat Tauopathies.
Carla PalleisJulia SauerbeckLeonie BeyerStefanie HarrisJulia SchmittEstrella Morenas-RodriguezAnika FinzeAlexander NitschmannFrancois Ruch-RubinsteinFlorian EckenweberGloria BiecheleTanja BlumeYuan ShiEndy WeidingerCatharina PrixKai BötzelAdrian DanekBoris-Stephan RauchmannSophia StöckleinSimon LindnerMarcus UnterrainerNathalie L AlbertChristian WetzelRainer RupprechtAxel RomingerPeter BartensteinJochen HermsRobert PerneczkyChristian HaassJohannes LevinGünter U HöglingerMatthias BrendelPublished in: Movement disorders : official journal of the Movement Disorder Society (2020)
Our data indicate that 18 F-GE-180 PET detects microglial activation in the brain of patients with 4-repeat tauopathy, fitting to predilection sites of the phenotype. The 18 kDa translocator protein PET has a potential for monitoring neuroinflammation in 4-repeat tauopathies. © 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Keyphrases
- lipopolysaccharide induced
- lps induced
- cerebral ischemia
- pet ct
- positron emission tomography
- computed tomography
- traumatic brain injury
- inflammatory response
- cognitive impairment
- pet imaging
- electronic health record
- white matter
- heat shock protein
- resting state
- protein protein
- brain injury
- blood brain barrier
- small molecule
- spinal cord injury
- human health
- functional connectivity
- clinical evaluation