Intra-abdominal temperature variation during hyperthermic intraperitoneal chemotherapy evaluated via computational fluid dynamics modeling.

Without intra-abdominal temperature monitoring at at-risk locations, it may be unfeasible to determine whether target temperatures and temperature homogeneity are being achieved during HIPEC. This work demonstrates that computational analysis offers the capability to monitor intra-abdominal locations at-risk of suboptimal heating and fluid flow given specific HIPEC parameters, and represents a first step towards designing efficacious tumor targeting during HIPEC.