Genetic features of B-cell lymphoblastic lymphoma with TCF3-PBX1.

Ryota Shirai Tomoo OsumiAiko Sato-OtsuboKazuhiko NakabayashiTakeshi MoriMasanori YoshidaKaoru YoshidaMika KohriTakashi IshiharaShiho YasueToshihiko ImamuraMikiya EndoSatoshi MiyamotoKentaro OhkiMasashi SanadaNobutaka KiyokawaSeishi OgawaTakako YoshiokaKenichiro HataMasatoshi Takagi Motohiro Kato

Published in: Cancer reports (Hoboken, N.J.) (2021)

In this study, through WES for seven patients with TCF3-PBX1-positive B-LBL, we identified KMT2D mutations and 6q LOH as recurrent alterations. In order to elucidate the relationship between these recurrent alterations and disease specificity or outcomes, further studies comparing with TCF3-PBX1-positive B-ALL are required.

Keyphrases

diffuse large b cell lymphoma
genome wide
gene expression
metabolic syndrome
copy number
insulin resistance
structural basis