Effect of conditioned medium of umbilical cord-derived mesenchymal stem cells as a culture medium for human granulosa cells: An experimental study.
Kanadi SumaprajaAndon HestiantoroIsabella Kurnia LiemArief BoedionoTeuku Z JacoebPublished in: International journal of reproductive biomedicine (2022)
IGF-1 produced by UC-MSCs-CM can work in paracrine fashion through the IGF receptor, which can inhibit BAX and maintain GDF9 production. Moreover, under the influence of UC-MSCs-CM, GC are also capable of producing IGF-1, which can impact GC through autocrine processes.
Keyphrases
- umbilical cord
- mesenchymal stem cells
- induced apoptosis
- binding protein
- pi k akt
- cell cycle arrest
- growth hormone
- endothelial cells
- signaling pathway
- bone marrow
- endoplasmic reticulum stress
- oxidative stress
- gas chromatography
- induced pluripotent stem cells
- mass spectrometry
- metabolic syndrome
- adipose tissue
- skeletal muscle
- insulin resistance