TLR4/ MyD88/NF-κB signaling pathway involved in the protective effect of diacerein against lung fibrosis in rats.

Asmaa Mohamed Abdel-AzizEman Mahmoud FathyHeba M HafezAmira F AhmedMervat Z Mohamed

Published in: Human & experimental toxicology (2023)

These results suggested the protective effect of diacerein on PF relies on its antioxidant and anti-inflammatory effects reducing TLR4/NF-κB signaling pathway.

Keyphrases

signaling pathway
toll like receptor
pi k akt
inflammatory response
nuclear factor
induced apoptosis
epithelial mesenchymal transition
immune response
oxidative stress
lps induced
anti inflammatory
cell proliferation
liver fibrosis