TLR4/ MyD88/NF-κB signaling pathway involved in the protective effect of diacerein against lung fibrosis in rats.
Asmaa Mohamed Abdel-AzizEman Mahmoud FathyHeba M HafezAmira F AhmedMervat Z MohamedPublished in: Human & experimental toxicology (2023)
These results suggested the protective effect of diacerein on PF relies on its antioxidant and anti-inflammatory effects reducing TLR4/NF-κB signaling pathway.