A Photosensitizer-Free Radical Cascade for Synthesizing CF 3 -Containing Polycyclic Quinazolinones with Visible Light.
Qiang HuWan-Lei YuYong-Chun LuoXiu-Qin HuPeng-Fei XuPublished in: The Journal of organic chemistry (2022)
Herein, we report an efficient photoinduced radical tandem trifluoromethylation/cyclization reaction of N -cyanamide alkenes for the synthesis of functionalized quinazolinones. Importantly, the reaction is carried out under mild conditions without any additional photosensitizer, metal, or extra additives. A series of trifluoromethyl quinazolinones were prepared efficiently with good yields and excellent functional group tolerance. Preliminary mechanistic experiments were conducted to indicate that the transformation proceeds via a possible mechanism involving photoexcited EDA complex and chain propagation.